Downregulates of ICAM1 expression in Myometrium from pregnant Rattus norvegicus infected with Tachyzoite of Toxoplasma gondii with Hyperbaric Oxygen Therapy

Arif Rahman Nurdianto, Arief and Aryati, Aryati and Mohammad Guritno Suryokusumo, Guritno and Mufasirin, Mufasirin (2019) Downregulates of ICAM1 expression in Myometrium from pregnant Rattus norvegicus infected with Tachyzoite of Toxoplasma gondii with Hyperbaric Oxygen Therapy. Hang Tuah Medical Journal, 17 (1). pp. 1-7. ISSN 1693-1238

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Abstract

Background: ICAM1 in pregnancy with Toxoplasma gondii infection can increase the number of Tachyzoite infections into the placenta and fetus. Hyperbaric Oxygen Therapy (HBOT) is often used and is safe in the treatment of anemia in pregnancy, besides HBOT can reduce ICAM1 through the induction of eNOS. It is hoped that HBOT therapy in pregnancy with Toxoplasmosis can prevent T. gondii from infecting the fetus. Material and Methods : This is an experimental study with a post-test only design on 37 pregnant Rattus norvegicus Sprague Dawley, then the rats were divided into 4 groups. The group A is pregnant rats infected with tachyzoite received Hyperbaric Oxygen Therapy (HBOT); the group B is Pregnant, not infected with tachyzoite and get HBOT; the group C is Pregnant and infected with tachyzoite T.gondii but not received HBOT, and group D consisted of normal pregnant rats that were not infected with tachyzoite and were not given HBOT. Rats were killed and the myometrial ICAM1 levels were measured with Immunohistochemistry examination. All data were analyzed with the ANOVA test with SPSS 21 Program. Results: The results show that HBOT can downregulate ICAM1 in the administered of HBOT 2.4 ATA for 3x30 minutes in 10 sessions over 5 days of therapy. Conclusion: The study concludes that HBOT can downregulate the expressions of ICAM1 in the myometrium, in the provision of HBO 2.4 ATA for 3x30 minutes in 10 sessions. Keywords: HBOT, ICAM1, Tachyzoite Toxoplasma gondii

Item Type:	Article
Subjects:	R Medicine > RS Pharmacy and materia medica
Depositing User:	Triani Febriana Triani
Date Deposited:	05 Aug 2020 04:22
Last Modified:	12 Nov 2020 09:37
URI:	http://repository.uam.ac.id/id/eprint/73

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